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Stephanie Reeve
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Year
Protein design algorithms predict viable resistance to an experimental antifolate
SM Reeve, P Gainza, KM Frey, I Georgiev, BR Donald, AC Anderson
Proceedings of the National Academy of Sciences 112 (3), 749-754, 2015
512015
Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus
S Keshipeddy, SM Reeve, AC Anderson, DL Wright
Journal of the American Chemical Society 137 (28), 8983-8990, 2015
392015
Charged nonclassical antifolates with activity against gram-positive and gram-negative pathogens
E Scocchera, SM Reeve, S Keshipeddy, MN Lombardo, B Hajian, ...
ACS medicinal chemistry letters 7 (7), 692-696, 2016
342016
Charged propargyl-linked antifolates reveal mechanisms of antifolate resistance and inhibit trimethoprim-resistant MRSA strains possessing clinically relevant mutations
SM Reeve, E Scocchera, JJ Ferreira, N G-Dayanandan, S Keshipeddy, ...
Journal of medicinal chemistry 59 (13), 6493-6500, 2016
292016
MRSA isolates from united states hospitals carry dfrg and dfrk resistance genes and succumb to propargyl-linked antifolates
SM Reeve, EW Scocchera, G Narendran, S Keshipeddy, J Krucinska, ...
Cell chemical biology 23 (12), 1458-1467, 2016
242016
Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis
B Hajian, E Scocchera, S Keshipeddy, N G-Dayanandan, C Shoen, ...
PloS one 11 (8), e0161740, 2016
212016
Novel cassette assay to quantify the outer membrane permeability of five β-lactams simultaneously in carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae
TH Kim, X Tao, B Moya, Y Jiao, KB Basso, J Zhou, Y Lang, DS Sutaria, ...
MBio 11 (1), 10.1128/mbio. 03189-19, 2020
182020
OSPREY predicts resistance mutations using positive and negative computational protein design
A Ojewole, A Lowegard, P Gainza, SM Reeve, I Georgiev, AC Anderson, ...
Computational Protein Design, 291-306, 2017
172017
Discovery and characterization of the antimetabolite action of thioacetamide-linked 1, 2, 3-triazoles as disruptors of cysteine biosynthesis in gram-negative bacteria
MJ Wallace, S Dharuman, DM Fernando, SM Reeve, CT Gee, J Yao, ...
ACS infectious diseases 6 (3), 467-478, 2019
152019
Toward broad spectrum dihydrofolate reductase inhibitors targeting trimethoprim resistant enzymes identified in clinical isolates of methicillin resistant Staphylococcus aureus
SM Reeve, D Si, J Krucinska, Y Yan, K Viswanathan, S Wang, GT Holt, ...
ACS Infectious Diseases 5 (11), 1896-1906, 2019
132019
A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance
D Leshchiner, F Rosconi, B Sundaresh, E Rudmann, LMN Ramirez, ...
Nature Communications 13 (1), 3165, 2022
122022
Combating multidrug‐resistant bacteria by integrating a novel target site penetration and receptor binding assay platform into translational modeling
Y Lang, NR Shah, X Tao, SM Reeve, J Zhou, B Moya, ARM Sayed, ...
Clinical Pharmacology & Therapeutics 109 (4), 1000-1020, 2021
122021
Azaindole based potentiator of antibiotics against gram-negative bacteria
S Sharma, R Rao, SM Reeve, GA Phelps, N Bharatham, ...
ACS Infectious Diseases 7 (11), 3009-3024, 2021
102021
Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery
SM Reeve, MN Lombardo, AC Anderson
Future microbiology 10 (11), 1727-1733, 2015
92015
Novel cassette assay to quantify the outer membrane permeability of five beta-lactams simultaneously in carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae …
TH Kim, X Tao, B Moya, Y Jiao, KB Basso, J Zhou, Y Lang, DS Sutaria, ...
82020
Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus
S Wang, SM Reeve, GT Holt, AA Ojewole, MS Frenkel, P Gainza, ...
PLoS computational biology 18 (2), e1009855, 2022
72022
Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins
S Dharuman, LA Wilt, J Liu, SM Reeve, CW Thompson, JM Elmore, ...
The Journal of antibiotics 74 (6), 381-396, 2021
62021
Structure-guided in vitro to in vivo pharmacokinetic optimization of propargyl-linked antifolates
MN Lombardo, N G-Dayanandan, S Keshipeddy, W Zhou, D Si, ...
Drug Metabolism and Disposition 47 (9), 995-1003, 2019
62019
G-Dayanadan
SM Reeve, EW Scocchera
N., Keshipeddy, S., Krucinska, J., Hajian, B., Ferreira, J., Nailor, M …, 2016
62016
G-Dayanandan, N.; Keshipeddy, S.; Wright, DL; Anderson, AC Charged propargyl-linked antifolates reveal mechanisms of antifolate resistance and inhibit trimethoprim-resistant …
SM Reeve, E Scocchera, JJ Ferreira
J. Med. Chem 59 (13), 6493-6500, 2016
62016
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