Isaac E. García Carrillo
Isaac E. García Carrillo
Associate Professor, Universidad de Valparaiso, PhD, Investigator, Centro Interdisciplinario de
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Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43
IE García, J Maripillán, O Jara, R Ceriani, A Palacios-Munoz, ...
Journal of Investigative Dermatology 135 (5), 1338-1347, 2015
Diseases associated with leaky hemichannels
MA Retamal, EP Reyes, IE García, B Pinto, AD Martínez, C González
Frontiers in cellular neuroscience 9, 267, 2015
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function
O Jara, R Acuña, IE García, J Maripillán, V Figueroa, JC Sáez, ...
Molecular biology of the cell 23 (17), 3299-3311, 2012
From hyperactive connexin26 hemichannels to impairments in epidermal calcium gradient and permeability barrier in the keratitis-ichthyosis-deafness syndrome
IE Garcia, F Bosen, P Mujica, A Pupo, C Flores-Munoz, O Jara, ...
Journal of Investigative Dermatology 136 (3), 574-583, 2016
Connexinopathies: a structural and functional glimpse
IE García, P Prado, A Pupo, O Jara, D Rojas-Gómez, P Mujica, ...
BMC cell biology 17 (1), 71-87, 2016
Characterization of a novel water pocket inside the human Cx26 hemichannel structure
R Araya-Secchi, T Perez-Acle, S Kang, T Huynh, A Bernardin, Y Escalona, ...
Biophysical journal 107 (3), 599-612, 2014
Abnormal distribution of inositol 1, 4, 5‐trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy‐derived cells
C Cárdenas, N Juretić, JA Bevilacqua, IE García, R Figueroa, R Hartley, ...
The FASEB Journal 24 (9), 3210-3221, 2010
Extracellular cysteine in connexins: role as redox sensors
MA Retamal, IE García, BI Pinto, A Pupo, D Báez, J Stehberg, R Del Rio, ...
Frontiers in physiology 7, 1, 2016
Role of connexin channels in the retinal light response of a diurnal rodent
A Palacios-Muñoz, MJ Escobar, A Vielma, J Araya, A Astudillo, G Valdivia, ...
Frontiers in cellular neuroscience 8, 249, 2014
The connexin26 human mutation N14K disrupts cytosolic intersubunit interactions and promotes channel opening
JM Valdez Capuccino, P Chatterjee, IE García, WM Botello-Smith, ...
Journal of General Physiology 151 (3), 328-341, 2019
Redox-mediated regulation of connexin proteins; focus on nitric oxide
IE Garcia, HA Sanchez, AD Martinez, MA Retamal
Biochimica et Biophysica Acta (BBA)-Biomembranes 1860 (1), 91-95, 2018
Charged residues at the first transmembrane region contribute to the voltage dependence of the slow gate of connexins
BI Pinto, IE García, A Pupo, MA Retamal, AD Martínez, R Latorre, ...
Journal of Biological Chemistry 291 (30), 15740-15752, 2016
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels
IE García, F Villanelo, GF Contreras, A Pupo, BI Pinto, JE Contreras, ...
Journal of General Physiology 150 (5), 697-711, 2018
Calcium binding and voltage gating in Cx46 hemichannels
BI Pinto, A Pupo, IE García, K Mena-Ulecia, AD Martínez, R Latorre, ...
Scientific reports 7 (1), 1-13, 2017
Insights on Gating Functions of Cytosolic Domains of Connexin26 Hemichannels Revealed by a Human Pathogenic Mutation (N14K)
JMV Capuccino, P Chatterjee, I Garcia, AL Harris, Y Luo, JE Contreras
Biophysical Journal 114 (3), 379a, 2018
Is the gain of hemichannel activity a common feature shared by Cx26 syndromic deafness mutants?
IE García, MA Retamal, O Jara, C González, AD Martínez
Biophysical Journal 104 (2), 492a-493a, 2013
Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling
C Flores-Muñoz, J Maripillán, J Vásquez-Navarrete, J Novoa-Molina, ...
International journal of molecular sciences 22 (3), 1069, 2021
Voltage Dependent Inhibition of Cx46 Hemichannels by Calcium
BI Pinto, A Pupo, I Garcia, K Mena-Ulecia, A Martinez, R Latorre, ...
Biophysical Journal 112 (3), 255a, 2017
11 Methods to Determine Formation of Heteromeric Hemichannels
AD Martínez, O Jara, R Ceriani, J Maripillán, P Mujica, IE García
Gap Junction Channels and Hemichannels, 239, 2016
Molecular Determinants Underlying the Pathogenic Mechanism of Kid Syndrome Elicited by Cx26G12R Mutation
IE García, G Contreras, A Pupo, B Pinto, R Latorre, JE Contreras, ...
Biophysical Journal 110 (3), 352a, 2016
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