Juan C Saez
Juan C Saez
Instituto de Neurociencias, Universidad de Valparaíso, Valparaíso, Chile (
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Plasma membrane channels formed by connexins: their regulation and functions
JC Sáez, VM Berthoud, MC Branes, AD Martinez, EC Beyer
Physiological reviews 83 (4), 1359-1400, 2003
Gap junctions: new tools, new answers, new questions
MVL Bennett, LC Barrio, TA Bargiello, DC Spray, EL Hertzberg, JC Saez
Neuron 6 (3), 305-320, 1991
Hepatocyte gap junctions are permeable to the second messenger, inositol 1, 4, 5-trisphosphate, and to calcium ions.
JC Saez, JA Connor, DC Spray, MV Bennett
Proceedings of the National Academy of Sciences 86 (8), 2708-2712, 1989
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
JE Contreras, HA Sánchez, EA Eugenín, D Speidel, M Theis, K Willecke, ...
Proceedings of the National Academy of Sciences 99 (1), 495-500, 2002
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia
MA Retamal, N Froger, N Palacios-Prado, P Ezan, PJ Sáez, JC Sáez, ...
Journal of Neuroscience 27 (50), 13781-13792, 2007
Connexin-based gap junction hemichannels: gating mechanisms
JC Sáez, MA Retamal, D Basilio, FF Bukauskas, MVL Bennett
Biochimica et Biophysica Acta (BBA)-Biomembranes 1711 (2), 215-224, 2005
Gating and regulation of connexin 43 (Cx43) hemichannels
JE Contreras, JC Sáez, FF Bukauskas, MVL Bennett
Proceedings of the National Academy of Sciences 100 (20), 11388-11393, 2003
New roles for astrocytes: gap junction hemichannels have something to communicate
MVL Bennett, JE Contreras, FF Bukauskas, JC Sáez
Trends in neurosciences 26 (11), 610-617, 2003
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.
JC Saez, DC Spray, AC Nairn, E Hertzberg, P Greengard, MV Bennett
Proceedings of the National Academy of Sciences 83 (8), 2473-2477, 1986
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
JA Orellana, N Froger, P Ezan, JX Jiang, MVL Bennett, CC Naus, ...
Journal of neurochemistry 118 (5), 826-840, 2011
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents
MA Retamal, CJ Cortés, L Reuss, MVL Bennett, JC Sáez
Proceedings of the National Academy of Sciences 103 (12), 4475-4480, 2006
Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.
AP Moreno, JC Sáez, GI Fishman, DC Spray
Circulation research 74 (6), 1050-1057, 1994
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue
JE Contreras, HA Sánchez, LP Véliz, FF Bukauskas, MVL Bennett, ...
Brain Research Reviews 47 (1-3), 290-303, 2004
Amyloid β-induced death in neurons involves glial and neuronal hemichannels
JA Orellana, KF Shoji, V Abudara, P Ezan, E Amigou, PJ Sáez, JX Jiang, ...
Journal of Neuroscience 31 (13), 4962-4977, 2011
Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures.
DC Spray, M Fujita, JC Saez, H Choi, T Watanabe, E Hertzberg, ...
The Journal of cell biology 105 (1), 541-551, 1987
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration
JA Orellana, PJ Sáez, KF Shoji, KA Schalper, N Palacios–Prado, ...
Antioxidants & redox signaling 11 (2), 369-399, 2009
Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-γ and tumor necrosis factor-α
EA Eugenín, D Eckardt, M Theis, K Willecke, MVL Bennett, JC Sáez
Proceedings of the National Academy of Sciences 98 (7), 4190-4195, 2001
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles
C Giaume, L Leybaert, C C. Naus, J C. Sáez
Frontiers in pharmacology 4, 88, 2013
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala
J Stehberg, R Moraga‐Amaro, C Salazar, A Becerra, C Echeverría, ...
The FASEB Journal 26 (9), 3649-3657, 2012
TNF-α plus IFN-γ induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses
EA Eugenín, MC Brañes, JW Berman, JC Sáez
The Journal of Immunology 170 (3), 1320-1328, 2003
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