| Mitochondria—judges and executioners of cell death sentences PD Bhola, A Letai Molecular cell 61 (5), 695-704, 2016 | 337 | 2016 |
| Developmental regulation of mitochondrial apoptosis by c-Myc governs age-and tissue-specific sensitivity to cancer therapeutics KA Sarosiek, C Fraser, N Muthalagu, PD Bhola, W Chang, SK McBrayer, ... Cancer cell 31 (1), 142-156, 2017 | 237 | 2017 |
| Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis D Lagares, A Santos, PE Grasberger, F Liu, CK Probst, RA Rahimi, ... Science translational medicine 9 (420), eaal3765, 2017 | 190 | 2017 |
| Functional precision oncology: testing tumors with drugs to identify vulnerabilities and novel combinations A Letai, P Bhola, AL Welm Cancer cell 40 (1), 26-35, 2022 | 120 | 2022 |
| Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control A Mahdavi, RE Davey, P Bhola, T Yin, PW Zandstra PLoS Computational Biology 3 (7), e130, 2007 | 87 | 2007 |
| MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia FC Brown, E Still, RP Koche, CY Yim, S Takao, P Cifani, C Reed, ... Cancer discovery 8 (4), 478-497, 2018 | 64 | 2018 |
| Spatial and temporal dynamics of mitochondrial membrane permeability waves during apoptosis PD Bhola, AL Mattheyses, SM Simon Biophysical journal 97 (8), 2222-2231, 2009 | 55 | 2009 |
| High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors PD Bhola, E Ahmed, JL Guerriero, E Sicinska, E Su, E Lavrova, J Ni, ... Science Signaling 13 (636), eaay1451, 2020 | 48 | 2020 |
| Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia PD Bhola, BG Mar, RC Lindsley, JA Ryan, LJ Hogdal, TT Vo, ... The Journal of clinical investigation 126 (10), 3827-3836, 2016 | 44 | 2016 |
| Determinism and divergence of apoptosis susceptibility in mammalian cells PD Bhola, SM Simon Journal of cell science 122 (23), 4296-4302, 2009 | 42 | 2009 |
| Pooled genomic screens identify anti-apoptotic genes as targetable mediators of chemotherapy resistance in ovarian cancer EH Stover, MB Baco, O Cohen, YY Li, EL Christie, M Bagul, A Goodale, ... Molecular Cancer Research 17 (11), 2281-2293, 2019 | 34 | 2019 |
| Synergistic interactions with PI3K inhibition that induce apoptosis Y Zwang, O Jonas, C Chen, ML Rinne, JG Doench, F Piccioni, L Tan, ... elife 6, e24523, 2017 | 32 | 2017 |
| Identification of novel therapeutic targets for fibrolamellar carcinoma using patient-derived xenografts and direct-from-patient screening G Lalazar, D Requena, L Ramos-Espiritu, D Ng, PD Bhola, YP De Jong, ... Cancer discovery 11 (10), 2544-2563, 2021 | 28 | 2021 |
| Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer DS Potter, R Du, P Bhola, R Bueno, A Letai Cell death & disease 12 (8), 1-12, 2021 | 20 | 2021 |
| Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics VW Daniels, JJ Zoeller, N Van Gastel, KE McQueeney, S Parvin, ... Science signaling 14 (686), eabc7405, 2021 | 13 | 2021 |
| High throughput BH3 profiling: a rapid and scalable technology to BH3 profile on low numbers of cells A Letai, P Bhola, J Ryan US Patent 10,761,086, 2020 | 10 | 2020 |
| Compositions and methods for assessing toxicity using dynamic bh3 profiling A Letai, P Bhola, R Jeremy | 8 | 2016 |
| Preclinical modeling of leiomyosarcoma identifies susceptibility to transcriptional CDK inhibitors through antagonism of E2F-driven oncogenic gene expression ML Hemming, P Bhola, MA Loycano, JA Anderson, ML Taddei, LA Doyle, ... Clinical Cancer Research 28 (11), 2397-2408, 2022 | 6 | 2022 |
| Live cell imaging dynamic bh3 profiling A Letai, P Bhola, R German US Patent App. 17/433,970, 2022 | 3 | 2022 |
| Compositions and methods for assessing toxicity using dynamic bh3 profiling A Letai, P Bhola, J Ryan US Patent App. 17/186,344, 2021 | 3 | 2021 |
