Gennady Poda
Gennady Poda
PhD, Scientific Advisor & Group Leader, Computational Chemistry and Chemoinformatics, OICR
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Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds
R Mannhold, GI Poda, C Ostermann, IV Tetko
Journal of pharmaceutical sciences 98 (3), 861-893, 2009
Can we estimate the accuracy of ADME–Tox predictions?
IV Tetko, P Bruneau, HW Mewes, DC Rohrer, GI Poda
Drug discovery today 11 (15-16), 700-707, 2006
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ...
Nature chemical biology 11 (8), 571-578, 2015
ToxAlerts: a web server of structural alerts for toxic chemicals and compounds with potential adverse reactions
I Sushko, E Salmina, VA Potemkin, G Poda, IV Tetko
Journal of chemical information and modeling 52 (8), 2310-2316, 2012
Unleashing the therapeutic potential of human kallikrein-related serine proteases
I Prassas, A Eissa, G Poda, EP Diamandis
Nature reviews Drug discovery 14 (3), 183-202, 2015
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
DR Anderson, MJ Meyers, WF Vernier, MW Mahoney, RG Kurumbail, ...
Journal of medicinal chemistry 50 (11), 2647-2654, 2007
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
G Senisterra, H Wu, A Allali-Hassani, GA Wasney, D Barsyte-Lovejoy, ...
Biochemical Journal 449 (1), 151-159, 2013
Application of ALOGPS 2.1 to predict log D distribution coefficient for Pfizer proprietary compounds
IV Tetko, GI Poda
Journal of medicinal chemistry 47 (23), 5601-5604, 2004
Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors
M Sanches, NM Duffy, M Talukdar, N Thevakumaran, D Chiovitti, ...
Nature communications 5 (1), 4202, 2014
Applications of neural networks in structure-activity relationships of a small number of molecules
IV Tetko, AI Luik, GI Poda
Journal of medicinal chemistry 36 (7), 811-814, 1993
A new, improved hybrid scoring function for molecular docking and scoring based on AutoDock and AutoDock Vina
VY Tanchuk, VO Tanin, AI Vovk, G Poda
Chemical biology & drug design 87 (4), 618-625, 2016
An Allosteric Inhibitor of Protein Arginine Methyltransferase 3
A Siarheyeva, G Senisterra, A Allali-Hassani, A Dong, E Dobrovetsky, ...
Structure, 2012
Functional characterization of a PROTAC directed against BRAF mutant V600E
G Posternak, X Tang, P Maisonneuve, T Jin, H Lavoie, S Daou, S Orlicky, ...
Nature chemical biology 16 (11), 1170-1178, 2020
Molecular modelling of the ORL1 receptor and its complex with nociceptin.
CM Topham, L Moulédous, G Poda, B Maigret, JC Meunier
Protein engineering 11 (12), 1163-1179, 1998
Structure-based optimization of a small molecule antagonist of the interaction between WD repeat-containing protein 5 (WDR5) and mixed-lineage leukemia 1 (MLL1)
M Getlik, D Smil, C Zepeda-Velazquez, Y Bolshan, G Poda, H Wu, A Dong, ...
Journal of medicinal chemistry 59 (6), 2478-2496, 2016
Condensation-driven assembly of boron-containing bis (heteroaryl) motifs using a linchpin approach
S Adachi, SK Liew, CF Lee, A Lough, Z He, JDS Denis, G Poda, AK Yudin
Organic letters 17 (22), 5594-5597, 2015
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system
LCK Wan, DYL Mao, D Neculai, J Strecker, D Chiovitti, I Kurinov, G Poda, ...
Nucleic acids research 41 (12), 6332-6346, 2013
Synthesis, optimization, and evaluation of novel small molecules as antagonists of WDR5-MLL interaction
Y Bolshan, M Getlik, E Kuznetsova, GA Wasney, T Hajian, G Poda, ...
ACS medicinal chemistry letters 4 (3), 353-357, 2013
Discovery of an MLLT1/3 YEATS domain chemical probe
M Moustakim, T Christott, OP Monteiro, J Bennett, C Giroud, J Ward, ...
Angewandte Chemie International Edition 57 (50), 16302-16307, 2018
Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency
DR Anderson, MJ Meyers, RG Kurumbail, N Caspers, GI Poda, SA Long, ...
Bioorganic & Medicinal Chemistry Letters 19 (16), 4882-4884, 2009
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