Peter Joseph O'Brien
Peter Joseph O'Brien
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Fit-for-purpose method development and validation for successful biomarker measurement
JW Lee, V Devanarayan, YC Barrett, R Weiner, J Allinson, S Fountain, ...
Pharmaceutical research 23, 312-328, 2006
Thrombin responses in human endothelial cells: contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
PJ O'Brien, N Prevost, M Molino, MK Hollinger, MJ Woolkalis, DS Woulfe, ...
Journal of Biological Chemistry 275 (18), 13502-13509, 2000
Toward ‘omic scale metabolite profiling: a dual separation–mass spectrometry approach for coverage of lipid and central carbon metabolism
J Ivanisevic, ZJ Zhu, L Plate, R Tautenhahn, S Chen, PJ O’Brien, ...
Analytical chemistry 85 (14), 6876-6884, 2013
The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins
PJ O’Brien, WE Alborn, JH Sloan, M Ulmer, A Boodhoo, MD Knierman, ...
Clinical chemistry 51 (2), 351-359, 2005
Protease activated receptors: theme and variations
PJ O'Brien, M Molino, M Kahn, LF Brass
Oncogene 20 (13), 1570-1581, 2001
Altered G Protein‐Coupling Functions of RNA Editing Isoform and Splicing Variant Serotonin2C Receptors
Q Wang, PJ O'Brien, CX Chen, DSC Cho, JM Murray, K Nishikura
Journal of neurochemistry 74 (3), 1290-1300, 2000
Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1
M Riewald, VV Kravchenko, RJ Petrovan, PJ O'Brien, LF Brass, ...
Blood, The Journal of the American Society of Hematology 97 (10), 3109-3116, 2001
Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
J Yang, J Wu, MA Kowalska, A Dalvi, N Prevost, PJ O'Brien, D Manning, ...
Proceedings of the National Academy of Sciences 97 (18), 9984-9989, 2000
Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report
JW Lee, RS Weiner, JM Sailstad, RR Bowsher, DW Knuth, PJ O’Brien, ...
Pharmaceutical research 22, 499-511, 2005
Evaluation of the substrate specificity of human mast cell tryptase βI and demonstration of its importance in bacterial infections of the lung
C Huang, GT De Sanctis, PJ O'Brien, JP Mizgerd, DS Friend, JM Drazen, ...
Journal of Biological Chemistry 276 (28), 26276-26284, 2001
Measurement of insulin-like growth factor-II in physiological fluids and tissues. I. An improved extraction procedure and radioimmunoassay for human and rat fluids
Endocrinology 128 (2), 805-814, 1991
[18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
CC Zhang, Z Yan, W Li, K Kuszpit, CL Painter, Q Zhang, PB Lappin, ...
Clinical Cancer Research 18 (5), 1303-1312, 2012
The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models
S Palsson, TP Hickling, EL Bradshaw-Pierce, M Zager, K Jooss, ...
BMC systems biology 7, 1-19, 2013
Genes that can be mutated to unmask hidden antigenic determinants in the cuticle of the nematode Caenorhabditis elegans.
SM Politz, M Philipp, M Estevez, PJ O'Brien, KJ Chin
Proceedings of the National Academy of Sciences 87 (8), 2901-2905, 1990
Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids
ME Kurczy, ZJ Zhu, J Ivanisevic, AM Schuyler, K Lalwani, AF Santidrian, ...
Nature communications 6 (1), 5998, 2015
Factor XIa–specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis
T David, YC Kim, LK Ely, I Rondon, H Gao, P O’Brien, MW Bolt, AJ Coyle, ...
Science translational medicine 8 (353), 353ra112-353ra112, 2016
Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging
PJ O’Brien, M Lee, ME Spilker, CC Zhang, Z Yan, TC Nichols, W Li, ...
Cancer & Metabolism 1 (1), 1-14, 2013
Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro
PJ O'Brien, H Koi, S Parry, LF Brass, JF Strauss III, LP Wang, ...
The American journal of pathology 163 (4), 1245-1254, 2003
Signal transduction during the initiation, extension, and perpetuation of platelet plug formation
D Woulfe, J Yang, N Prevost, PJ O’Brien, LF Brass
Platelets, 197-213, 2002
Recommendations for the evaluation of specimen stability for flow cytometric testing during drug development
L Brown, CL Green, N Jones, JJ Stewart, S Fraser, K Howell, Y Xu, ...
Journal of Immunological Methods 418, 1-8, 2015
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