Leandro Castellano
Leandro Castellano
Team Leader at University of Sussex and Imperial College London, UK
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Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia
V Fulci, S Chiaretti, M Goldoni, G Azzalin, N Carucci, S Tavolaro, ...
Blood, The Journal of the American Society of Hematology 109 (11), 4944-4951, 2007
The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response
L Castellano, G Giamas, J Jacob, RC Coombes, W Lucchesi, ...
Proceedings of the National Academy of Sciences 106 (37), 15732-15737, 2009
5′ isomiR variation is of functional and evolutionary importance
GC Tan, E Chan, A Molnar, R Sarkar, D Alexieva, IM Isa, S Robinson, ...
Nucleic acids research 42 (14), 9424-9435, 2014
MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression
AE Frampton, L Castellano, T Colombo, E Giovannetti, J Krell, J Jacob, ...
Gastroenterology 146 (1), 268-277. e18, 2014
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer
A Harrod, J Fulton, VTM Nguyen, M Periyasamy, L Ramos-Garcia, CF Lai, ...
Oncogene 36 (16), 2286-2296, 2017
MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors
LR Jiao, AE Frampton, J Jacob, L Pellegrino, J Krell, G Giamas, N Tsim, ...
PloS one 7 (2), e32068, 2012
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer
G Giamas, A Filipović, J Jacob, W Messier, H Zhang, D Yang, W Zhang, ...
Nature medicine 17 (6), 715-719, 2011
Mammosphere formation assay from human breast cancer tissues and cell lines
Y Lombardo, A de Giorgio, CR Coombes, J Stebbing, L Castellano
JoVE (Journal of Visualized Experiments), e52671, 2015
Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden
AE Frampton, MM Prado, E López-Jiménez, AB Fajardo-Puerta, ...
Oncotarget 9 (27), 19006, 2018
Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues
L Castellano, J Stebbing
Nucleic acids research 41 (5), 3339-3351, 2013
Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets
CE Macdougall, EG Wood, J Loschko, V Scagliotti, FC Cassidy, ...
Cell metabolism 27 (3), 588-601. e4, 2018
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion
VTM Nguyen, I Barozzi, M Faronato, Y Lombardo, JH Steel, N Patel, ...
Nature communications 6 (1), 10044, 2015
miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts
L Pellegrino, J Stebbing, VM Braga, AE Frampton, J Jacob, L Buluwela, ...
Nucleic acids research 41 (10), 5400-5412, 2013
microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis
AE Frampton, J Krell, NB Jamieson, TMH Gall, E Giovannetti, N Funel, ...
European journal of cancer 51 (11), 1389-1404, 2015
Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis
L Roca-Alonso, L Castellano, A Mills, AF Dabrowska, MB Sikkel, ...
Cell death & disease 6 (5), e1754-e1754, 2015
TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression
S Ottaviani, J Stebbing, AE Frampton, S Zagorac, J Krell, A de Giorgio, ...
Nature communications 9 (1), 1845, 2018
miR‐515‐5p controls cancer cell migration through MARK 4 regulation
OE Pardo, L Castellano, CE Munro, Y Hu, F Mauri, J Krell, R Lara, ...
EMBO reports 17 (4), 570-584, 2016
Novel tumour suppressive protein encoded by circular RNA, circ-SHPRH, in glioblastomas
S Begum, A Yiu, J Stebbing, L Castellano
Oncogene 37 (30), 4055-4057, 2018
Emerging roles of competing endogenous RNAs in cancer: insights from the regulation of PTEN
A de Giorgio, J Krell, V Harding, J Stebbing, L Castellano
Molecular and cellular biology, 2013
Downregulation of microRNA-515-5p by the estrogen receptor modulates sphingosine kinase 1 and breast cancer cell proliferation
FG Pinho, AE Frampton, J Nunes, J Krell, H Alshaker, J Jacob, ...
Cancer research 73 (19), 5936-5948, 2013
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