Yuan Xiong
Yuan Xiong
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Cells navigate with a local-excitation, global-inhibition-biased excitable network
Y Xiong, CH Huang, PA Iglesias, PN Devreotes
Proceedings of the National Academy of Sciences 107 (40), 17079-17086, 2010
PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis
L Chen, M Iijima, M Tang, MA Landree, YE Huang, Y Xiong, PA Iglesias, ...
Developmental cell 12 (4), 603-614, 2007
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis
Y Kamimura, Y Xiong, PA Iglesias, O Hoeller, P Bolourani, PN Devreotes
Current Biology 18 (14), 1034-1043, 2008
Lineage mapping the pre-implantation mouse embryo by two-photon microscopy, new insights into the segregation of cell fates
K McDole, Y Xiong, PA Iglesias, Y Zheng
Developmental biology 355 (2), 239-249, 2011
A novel white blood cell segmentation scheme based on feature space clustering
K Jiang, QM Liao, Y Xiong
Soft Computing 10, 12-19, 2006
Ceftazidime‐avibactam population pharmacokinetic modeling and pharmacodynamic target attainment across adult indications and patient subgroups
J Li, M Lovern, ML Green, J Chiu, D Zhou, C Comisar, Y Xiong, J Hing, ...
Clinical and Translational Science 12 (2), 151-163, 2019
A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model
H KM, L A, B J, R M, E S, F S, de Leon H, S A, X Y, S R, S H, W R, K AG
American Journal of Physiology - Regulatory, Integrative and Comparative …, 2014
Nonlinear mixed‐effects model development and simulation using nlmixr and related R open‐source packages
M Fidler, JJ Wilkins, R Hooijmaijers, TM Post, R Schoemaker, MN Trame, ...
CPT: pharmacometrics & systems pharmacology 8 (9), 621-633, 2019
Automated characterization of cell shape changes during amoeboid motility by skeletonization
Y Xiong, C Kabacoff, J Franca-Koh, PN Devreotes, DN Robinson, ...
BMC systems biology 4, 1-18, 2010
tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis
L Tang, J Franca-Koh, Y Xiong, MY Chen, Y Long, RM Bickford, ...
Genes & development 22 (16), 2278-2290, 2008
Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects
K Han, M Baker, M Lovern, P Paul, Y Xiong, P Patel, KP Moore, CS Seal, ...
British Journal of Clinical Pharmacology 88 (10), 4607-4622, 2022
Tools for analyzing cell shape changes during chemotaxis
Y Xiong, PA Iglesias
Integrative Biology 2 (11-12), 561-567, 2010
Population pharmacokinetics of trastuzumab deruxtecan in patients with HER2‐positive breast cancer and other solid tumors
O Yin, Y Xiong, S Endo, K Yoshihara, T Garimella, M AbuTarif, R Wada, ...
Clinical Pharmacology & Therapeutics 109 (5), 1314-1325, 2021
Dynacortin facilitates polarization of chemotaxing cells
C Kabacoff, Y Xiong, R Musib, EM Reichl, J Kim, PA Iglesias, ...
BMC biology 5, 1-15, 2007
Effects of renal impairment on steady-state plasma concentrations of rivastigmine: a population pharmacokinetic analysis of capsule and patch formulations in patients with …
G Lefevre, F Callegari, S Gsteiger, Y Xiong
Drugs & aging 33, 725-736, 2016
Model‐informed drug repurposing: a pharmacometric approach to novel pathogen preparedness, response and retrospection
M Dodds, Y Xiong, S Mouksassi, CM Kirkpatrick, K Hui, E Doyle, K Patel, ...
British journal of clinical pharmacology 87 (9), 3388-3397, 2021
nlmixr: Nonlinear mixed effects models in population pharmacokinetics and pharmacodynamics
M Fidler, Y Xiong, R Schoemaker, J Wilkins, M Trame, T Post, W Wang
R package version 2 (1), 2021
Performance of the SAEM and FOCEI algorithms in the open‐source, nonlinear mixed effect modeling tool nlmixr
R Schoemaker, M Fidler, C Laveille, JJ Wilkins, R Hooijmaijers, TM Post, ...
CPT: Pharmacometrics & Systems Pharmacology 8 (12), 923-930, 2019
Population pharmacokinetics and exposure‐response modeling of daratumumab subcutaneous administration in patients with light‐chain amyloidosis
M Luo, P Zhu, I Nnane, Y Xiong, G Merlini, RL Comenzo, E Kastritis, ...
The Journal of Clinical Pharmacology 62 (5), 656-669, 2022
R and nlmixr as a gateway between statistics and pharmacometrics
M Fidler, R Hooijmaijers, R Schoemaker, JJ Wilkins, Y Xiong, W Wang
CPT: Pharmacometrics & Systems Pharmacology 10 (4), 283, 2021
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