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John-Patrick Alao
John-Patrick Alao
Dirección de correo verificada de essex.ac.uk
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The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention
JP Alao
Molecular cancer 6, 1-16, 2007
10012007
Histone deacetylase inhibitor trichostatin A represses estrogen receptor α-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma …
JP Alao, EWF Lam, S Ali, L Buluwela, W Bordogna, P Lockey, ...
Clinical Cancer Research 10 (23), 8094-8104, 2004
1522004
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells
JP Alao, AV Stavropoulou, EWF Lam, R Charles Coombes, DM Vigushin
Molecular cancer 5, 1-11, 2006
1192006
Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice
L Sanderson, GW Taylor, EO Aboagye, JP Alao, JR Latigo, RC Coombes, ...
Drug metabolism and disposition 32 (10), 1132-1138, 2004
1152004
ICI182, 780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor α from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer …
R Varshochi, F Halim, A Sunters, JP Alao, PA Madureira, SM Hart, S Ali, ...
Journal of Biological Chemistry 280 (5), 3185-3196, 2005
962005
The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
JP Alao, SC Gamble, AV Stavropoulou, KM Pomeranz, EWF Lam, ...
Molecular Cancer 5, 1-11, 2006
862006
In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3′-deoxy-3′-[18F] fluorothymidine positron emission tomography
J Leyton, JP Alao, M Da Costa, AV Stavropoulou, JR Latigo, M Perumal, ...
Cancer Research 66 (15), 7621-7629, 2006
842006
Design, synthesis, and biological evaluation of chromone-based p38 MAP kinase inhibitors
C Dyrager, LN Mollers, LK Kjall, JP Alao, P Dinér, FK Wallner, ...
Journal of medicinal chemistry 54 (20), 7427-7431, 2011
672011
Preparation of 3-Substituted-1-Isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET Kinase Inhibitors
P Dinér, JP Alao, J Söderlund, P Sunnerhagen, M Grøtli
Journal of Medicinal Chemistry 55 (10), 4872-4876, 2012
632012
T: G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
MJ Lucey, D Chen, J Lopez-Garcia, SM Hart, F Phoenix, R Al-Jehani, ...
Nucleic acids research 33 (19), 6393-6404, 2005
592005
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation
JP Alao, P Sunnerhagen
Radiation Oncology 4, 1-7, 2009
562009
Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells
JP Alao, AV Stavropoulou, EWF Lam, RC Coombes
Molecular cancer 5, 1-6, 2006
532006
Flemingins G–O, Cytotoxic and Antioxidant Constituents of the Leaves of Flemingia grahamiana
I Gumula, JP Alao, IO Ndiege, P Sunnerhagen, A Yenesew, M Erdélyi
Journal of Natural Products 77 (9), 2060-2067, 2014
442014
Antiplasmodial quinones from Pentas longiflora and Pentas lanceolata
M Endale, JP Alao, HM Akala, NK Rono, FL Eyase, S Derese, A Ndakala, ...
Planta medica 78 (01), 31-35, 2012
382012
The nuclear oxysterol receptor LXRα is expressed in the normal human breast and in breast cancer
DM Vigushin, Y Dong, L Inman, N Peyvandi, JP Alao, C Sun, S Ali, ...
Medical Oncology 21, 123-131, 2004
372004
Anthraquinones of the Roots of Pentas micrantha
M Endale, A Ekberg, JP Alao, HM Akala, A Ndakala, P Sunnerhagen, ...
Molecules 18 (1), 311-321, 2012
362012
Rad3 and Sty1 function in Schizosaccharomyces pombe: an integrated response to DNA damage and environmental stress?
JP Alao, P Sunnerhagen
Molecular microbiology 68 (2), 246-254, 2008
342008
Cytotoxic Quinones from the Roots of Aloe dawei
N Abdissa, M Induli, P Fitzpatrick, JP Alao, P Sunnerhagen, G Landberg, ...
Molecules 19 (3), 3264-3273, 2014
282014
Structure–activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase
CM Marson, T Mahadevan, J Dines, S Sengmany, JM Morrell, JP Alao, ...
Bioorganic & medicinal chemistry letters 17 (1), 136-141, 2007
272007
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E, 4E)-5-arylpenta-2, 4-dienoic acid hydroxyamides
CM Marson, N Serradji, AS Rioja, SP Gastaud, JP Alao, RC Coombes, ...
Bioorganic & medicinal chemistry letters 14 (10), 2477-2481, 2004
262004
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Artículos 1–20