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Tinghu Zhang
Tinghu Zhang
Dana-Farber Cancer Institute
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Systematic identification of genomic markers of drug sensitivity in cancer cells
MJ Garnett, EJ Edelman, SJ Heidorn, CD Greenman, A Dastur, KW Lau, ...
Nature 483 (7391), 570-575, 2012
25522012
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
N Kwiatkowski, T Zhang, PB Rahl, BJ Abraham, J Reddy, SB Ficarro, ...
Nature 511 (7511), 616-620, 2014
8322014
Developing irreversible inhibitors of the protein kinase cysteinome
Q Liu, Y Sabnis, Z Zhao, T Zhang, SJ Buhrlage, LH Jones, NS Gray
Chemistry & biology 20 (2), 146-159, 2013
7102013
CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer
E Chipumuro, E Marco, CL Christensen, N Kwiatkowski, T Zhang, ...
Cell 159 (5), 1126-1139, 2014
6162014
Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor
CL Christensen, N Kwiatkowski, BJ Abraham, J Carretero, F Al-Shahrour, ...
Cancer cell 26 (6), 909-922, 2014
4502014
Plasticity in binding confers selectivity in ligand-induced protein degradation
RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ...
Nature chemical biology 14 (7), 706-714, 2018
4472018
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
CM Olson, B Jiang, MA Erb, Y Liang, ZM Doctor, Z Zhang, T Zhang, ...
Nature chemical biology 14 (2), 163-170, 2018
4322018
CDK7-dependent transcriptional addiction in triple-negative breast cancer
Y Wang, T Zhang, N Kwiatkowski, BJ Abraham, TI Lee, S Xie, H Yuzugullu, ...
Cell 163 (1), 174-186, 2015
4232015
Discovery of potent and selective covalent inhibitors of JNK
T Zhang, F Inesta-Vaquera, M Niepel, J Zhang, SB Ficarro, T Machleidt, ...
Chemistry & biology 19 (1), 140-154, 2012
3532012
Partitioning of cancer therapeutics in nuclear condensates
IA Klein, A Boija, LK Afeyan, SW Hawken, M Fan, A Dall'Agnese, O Oksuz, ...
Science 368 (6497), 1386-1392, 2020
3222020
Treatment-induced tumor dormancy through YAP-mediated transcriptional reprogramming of the apoptotic pathway
KJ Kurppa, Y Liu, C To, T Zhang, M Fan, A Vajdi, EH Knelson, Y Xie, ...
Cancer cell 37 (1), 104-122. e12, 2020
3222020
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
T Zhang, N Kwiatkowski, CM Olson, SE Dixon-Clarke, BJ Abraham, ...
Nature chemical biology 12 (10), 876-884, 2016
3052016
YAP drives growth by controlling transcriptional pause release from dynamic enhancers
GG Galli, M Carrara, WC Yuan, C Valdes-Quezada, B Gurung, ...
Molecular cell 60 (2), 328-337, 2015
2712015
A quantitative tissue-specific landscape of protein redox regulation during aging
H Xiao, MP Jedrychowski, DK Schweppe, EL Huttlin, Q Yu, DE Heppner, ...
Cell 180 (5), 968-983. e24, 2020
2612020
Light-induced control of protein destruction by opto-PROTAC
J Liu, H Chen, L Ma, Z He, D Wang, Y Liu, Q Lin, T Zhang, N Gray, ...
Science advances 6 (8), eaay5154, 2020
2482020
Allele-specific chromatin recruitment and therapeutic vulnerabilities of ESR1 activating mutations
R Jeselsohn, JS Bergholz, M Pun, MI Cornwell, W Liu, A Nardone, T Xiao, ...
Cancer cell 33 (2), 173-186. e5, 2018
2372018
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ...
elife 8, e45457, 2019
2152019
Development of dual and selective degraders of cyclin‐dependent kinases 4 and 6
B Jiang, ES Wang, KA Donovan, Y Liang, ES Fischer, T Zhang, NS Gray
Angewandte Chemie International Edition 58 (19), 6321-6326, 2019
2062019
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ...
Cell chemical biology 26 (2), 300-306. e9, 2019
2042019
CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation
M Krajewska, R Dries, AV Grassetti, S Dust, Y Gao, H Huang, B Sharma, ...
Nature communications 10 (1), 1757, 2019
1972019
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