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lars klareskog
lars klareskog
professor in rheumatology Karolinska Institutet
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Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised …
L Klareskog, D van der Heijde, JP de Jager, A Gough, J Kalden, ...
The Lancet 363 (9410), 675-681, 2004
22252004
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Y Okada, D Wu, G Trynka, T Raj, C Terao, K Ikari, Y Kochi, K Ohmura, ...
Nature 506 (7488), 376-381, 2014
19292014
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review
D Tracey, L Klareskog, EH Sasso, JG Salfeld, PP Tak
Pharmacology & therapeutics 117 (2), 244-279, 2008
19012008
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination
L Klareskog, P Stolt, K Lundberg, H Källberg, C Bengtsson, J Grunewald, ...
Arthritis & Rheumatism: Official Journal of the American College of …, 2006
17962006
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
EA Stahl, S Raychaudhuri, EF Remmers, G Xie, S Eyre, BP Thomson, Y Li, ...
Nature genetics 42 (6), 508-514, 2010
14082010
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
EF Remmers, RM Plenge, AT Lee, RR Graham, G Hom, TW Behrens, ...
New England Journal of Medicine 357 (10), 977-986, 2007
12002007
EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics …
B Combe, R Landewé, C Lukas, HD Bolosiu, F Breedveld, M Dougados, ...
Annals of the rheumatic diseases 66 (1), 34-45, 2007
11392007
TRAF1–C5 as a risk locus for rheumatoid arthritis—a genomewide study
RM Plenge, M Seielstad, L Padyukov, AT Lee, EF Remmers, B Ding, ...
New England Journal of Medicine 357 (12), 1199-1209, 2007
9872007
Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis
E Baecklund, A Iliadou, J Askling, A Ekbom, C Backlin, F Granath, ...
Arthritis & Rheumatism 54 (3), 692-701, 2006
9312006
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
Y Liu, MJ Aryee, L Padyukov, MD Fallin, E Hesselberg, A Runarsson, ...
Nature biotechnology 31 (2), 142-147, 2013
9002013
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
S Raychaudhuri, C Sandor, EA Stahl, J Freudenberg, HS Lee, X Jia, ...
Nature genetics 44 (3), 291-296, 2012
8702012
A gene–environment interaction between smoking and shared epitope genes in HLA–DR provides a high risk of seropositive rheumatoid arthritis
L Padyukov, C Silva, P Stolt, L Alfredsson, L Klareskog
Arthritis & Rheumatism: Official Journal of the American College of …, 2004
8112004
Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases
P Stolt, C Bengtsson, B Nordmark, S Lindblad, I Lundberg, L Klareskog, ...
Annals of the rheumatic diseases 62 (9), 835-841, 2003
8062003
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
U Harre, D Georgess, H Bang, A Bozec, R Axmann, E Ossipova, ...
The Journal of clinical investigation 122 (5), 1791-1802, 2012
7262012
Incidence of cancer among patients with rheumatoid arthritis
G Gridley, JK McLaughlin, A Ekbom, L Klareskog, HO Adami, DG Hacker, ...
JNCI: Journal of the National Cancer Institute 85 (4), 307-311, 1993
7161993
Golimumab, a human antibody to tumour necrosis factor α given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study
EC Keystone, MC Genovese, L Klareskog, EC Hsia, ST Hall, PC Miranda, ...
Annals of the rheumatic diseases 68 (6), 789-796, 2009
6822009
Replication of putative candidate-gene associations with rheumatoid arthritis in> 4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4 …
RM Plenge, L Padyukov, EF Remmers, S Purcell, AT Lee, EW Karlson, ...
The American Journal of Human Genetics 77 (6), 1044-1060, 2005
6782005
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two‐year clinical and radiographic results from the TEMPO study, a …
D van der Heijde, L Klareskog, V Rodriguez‐Valverde, C Codreanu, ...
Arthritis & Rheumatism 54 (4), 1063-1074, 2006
6702006
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
S Eyre, J Bowes, D Diogo, A Lee, A Barton, P Martin, A Zhernakova, ...
Nature genetics 44 (12), 1336-1340, 2012
6492012
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
RM Plenge, C Cotsapas, L Davies, AL Price, PIW De Bakker, J Maller, ...
Nature genetics 39 (12), 1477-1482, 2007
6422007
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Artículos 1–20