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Nicholas Cilfone
Nicholas Cilfone
Fidelity Investments (Artificial Intelligence & Machine Learning Center of Excellence)
Dirección de correo verificada de fmr.com - Página principal
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Dynamic balance of pro‐and anti‐inflammatory signals controls disease and limits pathology
JM Cicchese, S Evans, C Hult, LR Joslyn, T Wessler, JA Millar, S Marino, ...
Immunological reviews 285 (1), 147-167, 2018
2182018
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
PY Chen, L Qin, G Li, Z Wang, JE Dahlman, J Malagon-Lopez, S Gujja, ...
Nature metabolism 1 (9), 912-926, 2019
2042019
Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection
S Marino, NA Cilfone, JT Mattila, JJ Linderman, JAL Flynn, DE Kirschner
Infection and immunity 83 (1), 324-338, 2015
1972015
Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection
NA Cilfone, CR Perry, DE Kirschner, JJ Linderman
PloS one 8 (7), e68680, 2013
1272013
Th17 cytokines differentiate obesity from obesity‐associated type 2 diabetes and promote TNF α production
B Ip, NA Cilfone, AC Belkina, J DeFuria, M Jagannathan‐Bogdan, M Zhu, ...
Obesity 24 (1), 102-112, 2016
1222016
Enhancing retrosynthetic reaction prediction with deep learning using multiscale reaction classification
JL Baylon, NA Cilfone, JR Gulcher, TW Chittenden
Journal of chemical information and modeling 59 (2), 673-688, 2019
1112019
M281, an anti‐FcRn antibody: pharmacodynamics, pharmacokinetics, and safety across the full range of IgG reduction in a first‐in‐human study
LE Ling, JL Hillson, RG Tiessen, T Bosje, MP van Iersel, DJ Nix, ...
Clinical Pharmacology & Therapeutics 105 (4), 1031-1039, 2019
1062019
Strategies for efficient numerical implementation of hybrid multi-scale agent-based models to describe biological systems
NA Cilfone, DE Kirschner, JJ Linderman
Cellular and molecular bioengineering 8, 119-136, 2015
1062015
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity–mediated antimicrobial responses with caseation during Mycobacterium …
NA Cilfone, CB Ford, S Marino, JT Mattila, HP Gideon, JAL Flynn, ...
The Journal of Immunology 194 (2), 664-677, 2015
732015
Chronic mTOR activation induces a degradative smooth muscle cell phenotype
G Li, M Wang, AW Caulk, NA Cilfone, S Gujja, L Qin, PY Chen, Z Chen, ...
The Journal of clinical investigation 130 (3), 1233-1251, 2020
722020
A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
E Pienaar, NA Cilfone, PL Lin, V Dartois, JT Mattila, JR Butler, JAL Flynn, ...
Journal of theoretical biology 367, 166-179, 2015
702015
Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium
N Ricard, RP Scott, CJ Booth, H Velazquez, NA Cilfone, JL Baylon, ...
Journal of Experimental Medicine 216 (8), 1874-1890, 2019
552019
Quantitative systems pharmacology approaches applied to microphysiological systems (MPS): data interpretation and multi‐MPS integration
J Yu, NA Cilfone, EM Large, U Sarkar, JS Wishnok, SR Tannenbaum, ...
CPT: Pharmacometrics & Systems Pharmacology 4 (10), 585-594, 2015
522015
A multi-scale approach to designing therapeutics for tuberculosis
JJ Linderman, NA Cilfone, E Pienaar, C Gong, DE Kirschner
Integrative biology 7 (5), 591-609, 2015
352015
CPT: pharmacometrics Syst
J Yu, NA Cilfone, EM Large, U Sarkar, JS Wishnok, SR Tannenbaum, ...
Pharmacol 4 (585), 10.1002, 2015
322015
Systems pharmacology approach toward the design of inhaled formulations of rifampicin and isoniazid for treatment of tuberculosis
NA Cilfone, E Pienaar, GM Thurber, DE Kirschner, JJ Linderman
CPT: pharmacometrics & systems pharmacology 4 (3), 193-203, 2015
302015
Molecular profiling of rheumatoid arthritis patients reveals an association between innate and adaptive cell populations and response to anti-tumor necrosis factor
V Farutin, T Prod’homme, K McConnell, N Washburn, P Halvey, CJ Etzel, ...
Arthritis Research & Therapy 21, 1-14, 2019
252019
Quantum processor-inspired machine learning in the biomedical sciences
RY Li, S Gujja, SR Bajaj, OE Gamel, N Cilfone, JR Gulcher, DA Lidar, ...
Patterns 2 (6), 2021
212021
Enhancing reproducibility of gene expression analysis with known protein functional relationships: the concept of well-associated protein
JR Pradines, V Farutin, NA Cilfone, A Ghavami, E Kurtagic, J Guess, ...
PLOS Computational Biology 16 (2), e1007684, 2020
32020
Computational modeling of granuloma formation in tuberculosis yields insights into both infection and treatment
NA Cilfone, E Pienaar, DE Kirschner, JJ Linderman
Biophysical Journal 106 (2), 644a, 2014
32014
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