| PER2 controls lipid metabolism by direct regulation of PPARγ B Grimaldi, MM Bellet, S Katada, G Astarita, J Hirayama, RH Amin, ... Cell metabolism 12 (5), 509-520, 2010 | 515 | 2010 |
| PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy RA Hegele, H Cao, C Frankowski, ST Mathews, T Leff Diabetes 51 (12), 3586-3590, 2002 | 343 | 2002 |
| Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. WW Li, MM Dammerman, JD Smith, S Metzger, JL Breslow, T Leff The Journal of clinical investigation 96 (6), 2601-2605, 1995 | 332 | 1995 |
| c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-γ1 and negatively regulates its transcriptional activity HS Camp, SR Tafuri, T Leff Endocrinology 140 (1), 392-397, 1999 | 302 | 1999 |
| Adipogenesis and fat-cell function in obesity and diabetes HS Camp, D Ren, T Leff Trends in molecular medicine 8 (9), 442-447, 2002 | 280 | 2002 |
| Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone. HS Camp, O Li, SC Wise, YH Hong, CL Frankowski, X Shen, ... Diabetes 49 (4), 539-547, 2000 | 270 | 2000 |
| AMP-activated protein kinase regulates HNF4α transcriptional activity by inhibiting dimer formation and decreasing protein stability YH Hong, US Varanasi, W Yang, T Leff Journal of Biological Chemistry 278 (30), 27495-27501, 2003 | 257 | 2003 |
| Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors W Yang, YH Hong, XQ Shen, C Frankowski, HS Camp, T Leff Journal of Biological Chemistry 276 (42), 38341-38344, 2001 | 252 | 2001 |
| Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels. M Chen, JL Breslow, W Li, T Leff Journal of lipid research 35 (11), 1918-1924, 1994 | 245 | 1994 |
| AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins T Leff Biochemical Society Transactions 31 (1), 224-227, 2003 | 220 | 2003 |
| Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply EP Mottillo, AE Bloch, T Leff, JG Granneman Journal of Biological Chemistry 287 (30), 25038-25048, 2012 | 205 | 2012 |
| Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. NS Shachter, T Hayek, T Leff, JD Smith, DW Rosenberg, A Walsh, ... The Journal of clinical investigation 93 (4), 1683-1690, 1994 | 183 | 1994 |
| Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level. T Leff, R Elkaim, CR Goding, P Jalinot, P Sassone-Corsi, M Perricaudet, ... Proceedings of the National Academy of Sciences 81 (14), 4381-4385, 1984 | 149 | 1984 |
| Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements. JD Smith, A Melian, T Leff, JL Breslow Journal of Biological Chemistry 263 (17), 8300-8308, 1988 | 147 | 1988 |
| Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance RH Amin, ST Mathews, HS Camp, L Ding, T Leff American Journal of Physiology-Endocrinology and Metabolism 298 (1), E28-E37, 2010 | 146 | 2010 |
| Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action. S Haubenwallner, AD Essenburg, BC Barnett, ME Pape, RB DeMattos, ... Journal of Lipid Research 36 (12), 2541-2551, 1995 | 146 | 1995 |
| Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma. M Wang, SC Wise, T Leff, TZ Su Diabetes 48 (2), 254-260, 1999 | 137 | 1999 |
| Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors. K Reue, T Leff, JL Breslow Journal of Biological Chemistry 263 (14), 6857-6864, 1988 | 117 | 1988 |
| Adiponectin and PPARγ: cooperative and interdependent actions of two key regulators of metabolism O Astapova, T Leff Vitamins & Hormones 90, 143-162, 2012 | 104 | 2012 |
| A novel potent antagonist of peroxisome proliferator-activated receptor γ blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes HS Camp, A Chaudhry, T Leff Endocrinology 142 (7), 3207-3213, 2001 | 104 | 2001 |
Rob HegeleWestern University, Robarts Research InstituteVerified email at robarts.ca
