| Milestones of Lynch syndrome: 1895–2015 HT Lynch, CL Snyder, TG Shaw, CD Heinen, MP Hitchins Nature Reviews Cancer 15 (3), 181-194, 2015 | 837 | 2015 |
| Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database BA Thompson, AB Spurdle, JP Plazzer, MS Greenblatt, K Akagi, ... Nature genetics 46 (2), 107-115, 2014 | 487 | 2014 |
| Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework SE Brnich, AN Abou Tayoun, FJ Couch, GR Cutting, MS Greenblatt, ... Genome medicine 12, 1-12, 2020 | 376 | 2020 |
| Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans DW Rosenberg, S Yang, DC Pleau, EJ Greenspan, RG Stevens, ... Cancer research 67 (8), 3551-3554, 2007 | 208 | 2007 |
| DNA repair and tumorigenesis: lessons from hereditary cancer syndromes CD Heinen, C Schmutte, R Fishel Cancer biology & therapy 1 (5), 477-485, 2002 | 140 | 2002 |
| The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway CD Heinen, KH Goss, JR Cornelius, GF Babcock, ES Knudsen, T Kowalik, ... Gastroenterology 123 (3), 751-763, 2002 | 105 | 2002 |
| Microsatellite instability in aberrant crypt foci from human colons CD Heinen, N Shivapurkar, Z Tang, J Groden, O Alabaster Cancer research 56 (23), 5339-5341, 1996 | 104 | 1996 |
| The mismatch repair-dependent DNA damage response: Mechanisms and implications D Gupta, CD Heinen DNA repair 78, 60-69, 2019 | 90 | 2019 |
| Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future LJ Rasmussen, CD Heinen, B Royer‐Pokora, M Drost, S Tavtigian, ... Human mutation 33 (12), 1617-1625, 2012 | 84 | 2012 |
| Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families CD Heinen Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 693 (1 …, 2010 | 82 | 2010 |
| Microsatellite instability in colorectal adenocarcinoma cell lines that have full-length adenomatous polyposis coli protein CD Heinen, D Richardson, R White, J Groden Cancer research 55 (21), 4797-4799, 1995 | 77 | 1995 |
| HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions CD Heinen, T Wilson, A Mazurek, M Berardini, C Butz, R Fishel Cancer Cell 1 (5), 469-478, 2002 | 75 | 2002 |
| Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer CD Heinen DNA repair 38, 127-134, 2016 | 59 | 2016 |
| hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51 KS Shim, C Schmutte, G Tombline, CD Heinen, R Fishel Journal of Biological Chemistry 279 (29), 30385-30394, 2004 | 59 | 2004 |
| Biochemical characterization of the human RAD51 protein: III. modulation of DNA binding by adenosine nucleotides G Tombline, CD Heinen, KS Shim, R Fishel Journal of Biological Chemistry 277 (17), 14434-14442, 2002 | 57 | 2002 |
| DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication KN Mohni, AS Mastrocola, P Bai, SK Weller, CD Heinen Journal of virology 85 (23), 12241-12253, 2011 | 55 | 2011 |
| Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways A Taghbalout, M Du, N Jillette, W Rosikiewicz, A Rath, CD Heinen, S Li, ... Nature communications 10 (1), 4296, 2019 | 54 | 2019 |
| ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage D Gupta, B Lin, A Cowan, CD Heinen Proceedings of the National Academy of Sciences 115 (7), 1523-1528, 2018 | 52 | 2018 |
| Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer RG Stevens, H Swede, CD Heinen, M Jablonski, M Grupka, B Ross, ... Cancer letters 248 (2), 262-268, 2007 | 50 | 2007 |
| Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents J Klapacz, LH Pottenger, BP Engelward, CD Heinen, GE Johnson, ... Mutation Research/Reviews in Mutation Research 767, 77-91, 2016 | 44 | 2016 |
