| The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein D Leonard, MJ Hart, JV Platko, A Eva, W Henzel, T Evans, RA Cerione Journal of Biological Chemistry 267 (32), 22860-22868, 1992 | 242 | 1992 |
| A GDP dissociation inhibitor that serves as a GTPase inhibitor for the Ras-like protein CDC42Hs MJ Hart, Y Maru, D Leonard, ON Witte, T Evans, RA Cerione Science 258 (5083), 812-815, 1992 | 228 | 1992 |
| Class D β-lactamases: a reappraisal after five decades DA Leonard, RA Bonomo, RA Powers Accounts of chemical research 46 (11), 2407-2415, 2013 | 154 | 2013 |
| Structures of the class D carbapenemases OXA-23 and OXA-146: mechanistic basis of activity against carbapenems, extended-spectrum cephalosporins, and aztreonam KCJ Kaitany, NV Klinger, CM June, ME Ramey, RA Bonomo, RA Powers, ... Antimicrobial agents and chemotherapy 57 (10), 4848-4855, 2013 | 101 | 2013 |
| Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun DA Leonard, N Rajaram, TK Kerppola Proceedings of the National Academy of Sciences 94 (10), 4913-4918, 1997 | 96 | 1997 |
| Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using fluorescence spectroscopy DA Leonard, T Evans, M Hart, RA Cerione, D Manor Biochemistry 33 (40), 12323-12328, 1994 | 91 | 1994 |
| Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem KD Schneider, CJ Ortega, NA Renck, RA Bonomo, RA Powers, ... Journal of molecular biology 406 (4), 583-594, 2011 | 87 | 2011 |
| Interaction between Cdc42Hs and RhoGDI is mediated through the Rho insert region WJ Wu, DA Leonard, A Richard, D Manor Journal of Biological Chemistry 272 (42), 26153-26158, 1997 | 83 | 1997 |
| The 1.4 Å crystal structure of the class D β-lactamase OXA-1 complexed with doripenem KD Schneider, ME Karpen, RA Bonomo, DA Leonard, RA Powers Biochemistry 48 (50), 11840-11847, 2009 | 73 | 2009 |
| A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors. JV Platko, DA Leonard, CN Adra, RJ Shaw, RA Cerione, B Lim Proceedings of the National Academy of Sciences 92 (7), 2974-2978, 1995 | 72 | 1995 |
| Mutation of the active site carboxy-lysine (K70) of OXA-1 β-lactamase results in a deacylation-deficient enzyme KD Schneider, CR Bethel, AM Distler, AM Hujer, RA Bonomo, ... Biochemistry 48 (26), 6136-6145, 2009 | 65 | 2009 |
| Biochemical studies of the mechanism of action of the Cdc42-GTPase-activating protein DA Leonard, R Lin, RA Cerione, D Manor Journal of Biological Chemistry 273 (26), 16210-16215, 1998 | 61 | 1998 |
| DNA sequence-dependent folding determines the divergence in binding specificities between Maf and other bZIP proteins M Dlakić, AV Grinberg, DA Leonard, TK Kerppola The EMBO Journal 20 (4), 828-840, 2001 | 60 | 2001 |
| Identification of a novel protein with GDP dissociation inhibitor activity for the ras‐like proteins CDC42Hs and Rac 1 CN Adra, J Ko, D Leonard, LJ Wirth, RA Cerione, B Lim Genes, Chromosomes and Cancer 8 (4), 253-261, 1993 | 59 | 1993 |
| DNA bending determines Fos–Jun heterodimer orientation DA Leonard, TK Kerppola nature structural biology 5 (10), 877-881, 1998 | 53 | 1998 |
| Use of a fluorescence spectroscopic readout to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3 DA Leonard, RS Satoskar, WJ Wu, S Bagrodia, RA Cerione, D Manor Biochemistry 36 (5), 1173-1180, 1997 | 52 | 1997 |
| Molecular basis of cooperative DNA bending and oriented heterodimer binding in the NFAT1—Fos–Jun—ARRE2 complex RJ Diebold, N Rajaram, DA Leonard, TK Kerppola Proceedings of the National Academy of Sciences 95 (14), 7915-7920, 1998 | 48 | 1998 |
| Structural origins of oxacillinase specificity in class D β-lactamases CM June, BC Vallier, RA Bonomo, DA Leonard, RA Powers Antimicrobial agents and chemotherapy 58 (1), 333-341, 2014 | 47 | 2014 |
| Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii JM Mitchell, JR Clasman, CM June, KCJ Kaitany, JR LaFleur, MA Taracila, ... Biochemistry 54 (10), 1976-1987, 2015 | 44 | 2015 |
| Inhibition of OXA-1 β-lactamase by penems CR Bethel, AM Distler, MW Ruszczycky, MP Carey, PR Carey, AM Hujer, ... Antimicrobial agents and chemotherapy 52 (9), 3135-3143, 2008 | 44 | 2008 |
