| State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications L Afzelius, C Hasselgren Arnby, A Broo, L Carlsson, C Isaksson, U Jurva, ... Drug metabolism reviews 39 (1), 61-86, 2007 | 152 | 2007 |
| Enhanced metabolite identification with MSE and a semi‐automated software for structural elucidation B Bonn, C Leandersson, F Fontaine, I Zamora Rapid Communications in Mass Spectrometry 24 (21), 3127-3138, 2010 | 104 | 2010 |
| Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: comparison of a primary hepatocyte/stromal cell co-culture with plated primary … B Bonn, P Svanberg, A Janefeldt, I Hultman, K Grime Drug Metabolism and Disposition 44 (4), 527-533, 2016 | 82 | 2016 |
| Exploration of enzyme− ligand interactions in CYP2D6 & 3A4 homology models and crystal structures using a novel computational approach B Kjellander, CM Masimirembwa, I Zamora Journal of chemical information and modeling 47 (3), 1234-1247, 2007 | 31 | 2007 |
| Facile production of minor metabolites for drug development using a CYP3A shuffled library DJB Hunter, J Behrendorff, WA Johnston, PY Hayes, W Huang, B Bonn, ... Metabolic engineering 13 (6), 682-693, 2011 | 29 | 2011 |
| Design and synthesis of soluble and cell-permeable PI3Kδ inhibitors for long-acting inhaled administration MWD Perry, K Björhall, B Bonn, J Carlsson, Y Chen, A Eriksson, ... Journal of Medicinal Chemistry 60 (12), 5057-5071, 2017 | 24 | 2017 |
| The molecular basis of CYP2D6-mediated N-dealkylation: balance between metabolic clearance routes and enzyme inhibition B Bonn, CM Masimirembwa, Y Aristei, I Zamora Drug metabolism and disposition 36 (11), 2199-2210, 2008 | 22 | 2008 |
| Montelukast disposition: no indication of transporter-mediated uptake in OATP2B1 and OATP1B1 expressing HEK293 cells M Brännström, P Nordell, B Bonn, AM Davis, AP Palmgren, C Hilgendorf, ... Pharmaceutics 7 (4), 554-564, 2015 | 19 | 2015 |
| Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl … M Munck af Rosenschöld, P Johannesson, A Nikitidis, C Tyrchan, ... Journal of Medicinal Chemistry 62 (17), 7769-7787, 2019 | 17 | 2019 |
| A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans FJ Caballero-Camino, PM Rodrigues, F Wångsell, A Agirre-Lizaso, ... Hepatology 78 (3), 709-726, 2023 | 15 | 2023 |
| Pulmonary metabolism of substrates for key drug-metabolizing enzymes by human alveolar type II cells, human and rat lung microsomes, and the isolated perfused rat lung model K Rubin, P Ewing, E Bäckström, A Abrahamsson, B Bonn, S Kamata, ... Pharmaceutics 12 (2), 117, 2020 | 15 | 2020 |
| Dietary thylakoids reduce visceral fat mass and increase expression of genes involved in intestinal fatty acid oxidation in high-fat fed rats EL Stenblom, E Egecioglu, C Montelius, D Ramachandran, B Bonn, ... American Journal of Physiology-Regulatory, Integrative and Comparative …, 2016 | 15 | 2016 |
| Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan B Bonn, CM Masimirembwa, N Castagnoli Drug metabolism and disposition 38 (1), 187-199, 2010 | 15 | 2010 |
| Dual role for a MEK inhibitor as a modulator of inflammation and host defense mechanisms with potential therapeutic application in COPD N Kurian, TS Cohen, L Öberg, E De Zan, G Skogberg, S Vollmer, ... International Journal of Chronic Obstructive Pulmonary Disease, 2611-2624, 2019 | 14 | 2019 |
| Hultman Ia, and Grime K (2016) Determination of human hepatocyte intrinsic clearance for slowly metabolized compounds: comparison of a primary hepatocyte/stromal cell co … B Bonn, P Svanberg, A Janefeldt Drug Metab Dispos 44, 527-533, 0 | 10 | |
| Mechanism-based insights into removing the mutagenicity of aromatic amines by small structural alterations I Shamovsky, L Ripa, F Narjes, B Bonn, S Schiesser, I Terstiege, ... Journal of Medicinal Chemistry 64 (12), 8545-8563, 2021 | 9 | 2021 |
| P15 The orally available sodium/taurocholate co-transporting polypeptide inhibitor A2342 blocks hepatitis B and D entry in vitro B Bonn, E Strängberg, I Uzelac, M Kirstgen, N Goldmann, D Glebe, ... Gut 71 (Suppl 3), A42-A42, 2022 | 5* | 2022 |
| Characterisation of artemisinin–chloroquinoline hybrids for potential metabolic liabilities R Thelingwani, C Leandersson, B Bonn, P Smith, K Chibale, ... Xenobiotica 46 (3), 234-240, 2016 | 5 | 2016 |
| Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity R Thelingwani, B Bonn, K Chibale, C Masimirembwa Expert Opinion on Drug Metabolism & Toxicology 10 (10), 1313-1324, 2014 | 5 | 2014 |
| The API B Bonn, M Perry Inhaled Medicines, 13-34, 2021 | 4 | 2021 |
